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  • Hope over 'repairing' sun cream

    Last Updated: Wednesday, 31 August 2005, 12:02 GMT 13:02 UK

    US scientists say they have developed a lotion which repairs sun damaged skin.

    The lotion, currently undergoing clinical trials, contains a protein which mends DNA damaged by the sun.

    AGI Dermatics said tests had shown the cream cut skin cancer rates when used daily for a year on people who were susceptible to the disease.

    Experts said it may encourage people to spend longer in the sun. AGI Dermatics stressed the cream was no alternative to sunscreen.

    Skin cancer kills more than 2,000 people a year in the UK. Oil sacs in the lotion allow a protein called T4 endonuclease to penetrate the skin cells.

    Once inside a cell's nucleus, the protein removes damaged areas of DNA and starts a repair process that the body completes.

    The lotion and the protein enter cells within an hour of application and produces measurable results within six hours, researchers from the New York firm told the American Chemical Society's annual conference.

    The lotion was tested on 30 people with a rare genetic disease, xeroderma pigmentosum, that made them more susceptible to skin cancer.

    Daily application of the lotion resulted in a third fewer skin cancers and two thirds fewer pre-cancer lesions than in those who did not use it.

    Lead researcher Daniel Yarosh said the cream had the potential to be used widespread in the fight to protect skin against the sun.

    "This is the first DNA repair drug and is a 'morning after' approach that is different than other sun protection efforts."

    Concern

    But Dr Mark Matfield, scientific consultant at the International Association of Cancer Research, said while the cream should not be dismissed as it showed potential, the causes of skin cancer were complicated and not fully understood so this treatment would probably not be the answer for all forms of the disease.

    And he added: "One of the main concerns is that this could lead to a laissez-faire attitude to sun care.

    "People may think we can repair the damage, but the truth is that it is better to prevent it in the first place."

    And Julie Sharp, senior science information officer for Cancer Research UK, said: "It should not be seen as a shortcut way of repairing the skin damage caused by sun bathing.

    "Preventing skin cancer in the first place is vital and we recommend people take care to protect themselves by avoiding sunburn, finding shade from the mid-day sun, covering up and using a high-factor sunscreen."

    http://news.bbc.co.uk/2/hi/health/4199992.stm
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  • #2
    alhamdulillah, covering sisters do not face this problem insha allah as we are protected from the sun by our clothes :) :D
    .: Rufaida :.
    .:Fa Firroo Ila-llaah:.
    http://s61.photobucket.com/albums/h6...th_Silence.jpg
    “People praise you for what they suppose is in you,
    but you must blame your soul for what you know is in you.”
    ~ Ibn Atallah

    Ramadan Activities for Children
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    • #3
      Technically...with the exception of the burqa, covering sisters can still get sunburn (on their face)
      You are not aware of the consequences that would result (if you were granted what you desire) because what you seek might be to your detriment. (O soul) be conscious that your Master is more aware about your well-being than you are.

      ~Ibn Al-Jawzee

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      • #4
        technically you can even get sunburn through your cloth,

        the thicker the material and darker the colour the less sun comes to your skin.

        and you only talk about sisters - what about the brothers?
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        • #5
          Well, the darker the colour, the more heat it absorbs.

          If you don't get sunburn you'll definitely get "prickly heat spots"

          What about the brothers? Sunburn applies for them as well - they certainly aren't immune to it.
          You are not aware of the consequences that would result (if you were granted what you desire) because what you seek might be to your detriment. (O soul) be conscious that your Master is more aware about your well-being than you are.

          ~Ibn Al-Jawzee

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          • #6
            Originally posted by Ebony
            Well, the darker the colour, the more heat it absorbs.

            If you don't get sunburn you'll definitely get "pricky heat spots"

            What about the brothers? Sunburn applies for them as well - they certainly aren't immune to it.
            Nah..........not really, in this country.........

            The sun and teh heat is'nt as profuse in other countries.
            Please Re-update your Signature

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            • #7
              I was only saying that covering protects us from sunburn.. it's true. I never got sunburned at all since I started covering. Yes, maybe people could stil b burnt on their face / hands... but its not AS likely, and compared to non muslims who you see on the tube with red peeling sunburn all over their back and shoulders etc.. we do not get so affected alhamdulillah
              .: Rufaida :.
              .:Fa Firroo Ila-llaah:.
              http://s61.photobucket.com/albums/h6...th_Silence.jpg
              “People praise you for what they suppose is in you,
              but you must blame your soul for what you know is in you.”
              ~ Ibn Atallah

              Ramadan Activities for Children
              <button id="tw_schedule_btn" class="tw-schedule-btn" style="padding: 4px 6px;position: absolute;left: 141px;top: 840px;background-color: #F7F7F7; background: linear-gradient(#FFF, #F0F0F0); border: 1px solid #CCC; color: #5F5F5F; cursor: pointer; font-weight: bold; text-shadow: 0 1px #FFF; white-space: nowrap;border-radius: 3px;font-size: 11px; display: none; z-index: 8675309">Schedule</button>

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              • #8
                I tend to burn in the sun easily. And im fully covered.
                Sunburn boils down to sun exposure (how much sun and for how long) and skin type.
                You are not aware of the consequences that would result (if you were granted what you desire) because what you seek might be to your detriment. (O soul) be conscious that your Master is more aware about your well-being than you are.

                ~Ibn Al-Jawzee

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                • #9
                  Sunburn does'nt affect me!!!!!!!

                  Pretty tanned as it is :D
                  Please Re-update your Signature

                  Comment


                  • #10
                    Key to why melanoma is so potent


                    Last Updated: Sunday, 4 September 2005, 23:10 GMT 00:10 UK




                    Skin cancer rates have been increasing across the UK


                    Scientists have discovered why a form of skin cancer called melanoma can be so malignant.

                    If not caught early the disease can spread through the body with an efficiency few other tumours possess.

                    Latest research suggests that, unlike other cancer cells, melanoma does not have to learn how to spread - it has that ability innately. The research, by Whitehead Institute for Biomedical Research in the US, is published in Nature Genetics.

                    Lead researcher Professor Robert Weinberg said: "Other cancers need to learn how to spread, but not melanoma.

                    "Now, for the first time, we understand the genetic mechanism responsible for this."

                    The spread of disease to an unconnected body part - known as metastasis - is a highly inefficient, multi-step process that requires cancer cells to jump through many hoops.

                    Slug gene

                    The cells first must invade a nearby tissue, then make their way into the blood or lymphatic vessels.

                    Next they must migrate through the bloodstream to a distant site, exit the bloodstream, and establish new colonies.

                    Researchers have wondered why melanoma in particular is able to do this not only more efficiently than other cancers, but at a far earlier stage.

                    The latest study shows that as melanocytes - cells that protect the skin from sun damage by producing pigmentation - morph into cancer cells, they immediately reawaken a dormant cellular process that lets them travel swiftly throughout the body.

                    Central to this reawakened process is a gene called Slug which plays a key role in allowing cells to travel around the developing embryo in the womb.

                    Normally the gene is shut off in adult tissues, but the researchers found that when skin cells become malignant they reactivate Slug, and thus immediately acquire the ability to spread.

                    Injected cells

                    The researchers injected cancer-causing genes into normal human cells and then injected the resulting tumours under the skin of mice.

                    Mice injected with breast or connective tissue cancer cells developed tumours - but these did not spread.

                    But those injected with melanoma cells immediately developed invasive tumours throughout their body.

                    Detailed analysis showed that Slug was expressed in the melanoma cells.

                    When the gene was knocked out in melanoma cells, the cancer was unable to spread when introduced into a mouse.

                    Professor Weinberg said: "This work is a demonstration of the notion that certain embryonic genes normally involved in transferring cells from one part of the body to another are also involved in enabling cancer cells to spread."

                    The same team last year showed a similar embryonic gene, Twist, played a role in the spread of certain forms of breast cancer.

                    Dr Julie Sharp, senior cancer information officer at Cancer Research UK, said: "If scientists can target treatments to block the Slug gene, they might be able to prevent cancer spread and improve survival from this disease in the future," she said.

                    "It is also important to remember that the vast majority of melanomas are caused by UV damage from excess sun exposure."

                    http://news.bbc.co.uk/2/hi/health/4207340.stm
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