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  • HIV 'could destroy cancer cells'

    Last Updated: Sunday, 13 February, 2005, 23:43 GMT

    US scientists hope to be able to use a harmless form of the Aids virus to seek and destroy cancer cells.

    A University of California team found an "impotent" version of HIV, with the disease-causing parts of it removed, tracked down cancer cells in mice.

    The next step would be to insert a gene into the virus that would kill the cancer upon contact.

    The team told Nature Medicine more safety studies were needed before such a method could be tested in humans.

    Gene therapy

    The mice they studied had a form of skin cancer, called melanoma, that had spread to the lungs.

    In the laboratory, the scientists took HIV and removed the parts of the virus that causes disease.

    They then stripped off the virus' outer coat and redressed it with the outer suit of another virus.

    By doing this, the researchers had changed the target of the virus.

    HIV normally infects immune cells called T cells. The new outer coat instead directed HIV to hunt down molecules present on cancer cells, called P-glycoproteins.

    The scientists also added a substance to the virus that would make it visibly glow when looked at with a special camera so they could track where it travelled once injected into the mice.

    Researcher Dr Irvin Chen, from UCLA's Aids Institute, said: "The virus travelled through the bloodstream and homed straight to the cancer cells in the lungs, where the melanoma had migrated.

    "Gene therapy has been hampered by the lack of a good carrier.

    "Our approach proves that it is possible to develop an effective carrier and reprogram it to target specific cells in the body."

    Beating cancer's spread

    His team is planning to see whether the virus could carry a therapeutic gene to the precise location of the cancer.

    As well as controlling cancer, they hope this technique might be useful for treating genetic diseases.

    Dr Georges Vassaux, from Cancer Research UK's clinical centre at Barts and The London, said: "This is the first time that a vector - or delivery system - for gene therapy has targeted a tumour in such a specific manner.

    "This means the technique could be used to use gene therapy in cases where cancer has spread around the body.

    "So far gene therapy has been successfully used only on tumours that are confined to their original location."

    He said there had been concerns that such methods might cause leukaemia in normal cells.

    "As the team has managed to target the therapy to cancer cells, it looks as though a hazard associated with the use of integrative viruses may have been overcome," he said.

    http://news.bbc.co.uk/1/hi/health/4257783.stm
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  • #2
    UCLA scientists transform HIV into cancer-seeking missile

    Public release date: 13-Feb-2005
    Contact: Elaine Schmidt
    [email protected]
    310-794-2272
    University of California - Los Angeles

    Firefly protein illuminates virus' hunt of metastasized melanoma cells in live mouse

    Camouflaging an impotent AIDS virus in new clothes enables it to hunt down metastasized melanoma cells in living mice, reports a UCLA AIDS Institute study in the Feb. 13 online edition of Nature Medicine
    The National Institute of Allergy and Infectious Diseases and National Cancer Institute funded the study. Kouki Morizono, Yiming Xie, Gene-Errol Ringpis, Mai Johnson, Hoorig Nassanian, Benur Lee and Lily Wu co-authored the research.

    http://www.eurekalert.org/pub_releas...-ust020905.php
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    • #3
      HIV may hold key to cancer cure

      This is a transcript from The World Today. The program is broadcast around Australia at 12:10pm on ABC Local Radio.

      You can also listen to the story in REAL AUDIO and WINDOWS MEDIA formats.

      The World Today - Tuesday, 15 February , 2005 12:21:00
      Reporter: Karen Barlow

      ELEANOR HALL: To an extraordinary good news twist on the disease which has been devastating communities around the world for decades, AIDS.

      Scientists have discovered that HIV, the virus which causes AIDS, could in fact hold the key to curing cancer.

      A research team from the University of California has disabled the AIDS causing parts of HIV and reprogrammed it as a cancer killer.

      And while it may be several years before the technique can be used in humans, this gene therapy is proving to be successful in research on mice, as Karen Barlow reports.

      KAREN BARLOW: Since the arrival of HIV in the later part of the last century, the virus which causes AIDS has cut a swathe through the world's population.

      Last year alone a record 3.1 million people died of AIDS, mostly in developing nations where anti-retroviral drugs are neither fully nor cheaply available.

      It has also caused fear, despair and misunderstanding.

      Any cure is a long way off and researchers are focusing efforts on a preventative vaccine or improving the lives of HIV positive people through combination drug therapies.

      But other researchers have been impressed by the virus's tenacity and killer instinct.

      Elizabeth Withers-Ward from the Los Angeles AIDS Institute at the University of California says HIV has proven the best carrier in cancer gene therapy trials on mice.

      ELIZABETH WITHERS-WARD: It's the perfect candidate in that it allows infection of, and integration of human cells, because it has the right machinery. It has the ability by the virus envelope or the outside of the virus, decorated with a protein, and that's, depending on what that protein is, it uses a certain cell on the outside of its host protein to bind and then get in.

      So in this case we've changed the envelope to bind to antibodies and then, the antibody, once bound, will hone to the type of cell that it binds to.

      KAREN BARLOW: The process would not led to an HIV infection, as Elizabeth Withers-Ward says the virus is stripped of its dangerous AIDS causing parts.

      ELIZABETH WITHERS-WARD: We have taken out about 80 per cent of the HIV sequences and in that way, disabled the virus. And what we've left is the little bits that are necessary to get the DNA into the cell and then get it into the cell DNA.

      It's a really profoundly important thing in gene therapy. It really is, because you can actually, in this case, specifically target the population of cells. It's the first time anyone's done that. I mean it's really cool.

      KAREN BARLOW: In the California trials, the reprogrammed viruses bound themselves to lung cancer cells. Elizabeth Withers-Ward says they could be reprogrammed to release their load of therapeutic genes on all types of cancer cells.

      ELIZABETH WITHERS-WARD: It's a tremendous powerful system and tool, precisely because you've modified the envelope to bind to antibodies and then, depending on what antibody you've put in there, it could bind to a lung tumour cell, a kidney tumour cell, you know, a brain tumour cell.

      So, you could imagine, I mean there are endless possibilities of how this might be used.

      KAREN BARLOW: And it'll certainly improve the reputation of HIV?

      ELIZABETH WITHERS-WARD: I think so. I mean, if people would sort of be challenged with thinking about that idea seriously in terms of therapy, a lot of testing would be done and I think then people might feel safer. So, it's taking a very negative virus as it were, a virus with a very negative potential and turning parts of it into a very positive thing

      ELEANOR HALL: Karen Barlow reporting.

      http://www.abc.net.au/worldtoday/con...5/s1303130.htm
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      • #4
        Re: HIV 'could destroy cancer cells'

        interesting concept

        using a man-made disease to fight a man-made disease
        .لا نريد زعيما يخاف البيت الإبيض
        نريد زعيما يخاف الواحد الأحد
        دولة الإسلامية باقية





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        • #5
          Re: HIV 'could destroy cancer cells'

          what do you mean by man made diseases?

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          • #6
            Re: HIV 'could destroy cancer cells'

            Abumubarak how is cancer man made

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            • #7
              Re: HIV 'could destroy cancer cells'

              Originally posted by Kashmir_85 View Post
              Abumubarak how is cancer man made
              The most prominent form of cancer is lung cancer. And an overwhelming majority (more than 99%) of lung cancer (actually, any cancer) patients inflict it on themselves. Smoking and the like.

              Comment


              • #8
                Re: HIV 'could destroy cancer cells'

                Originally posted by Kashmir_85 View Post
                Abumubarak how is cancer man made
                my understanding from my rather limited knowledge of holistic medicine and foods is that the foreign items that we introduce into our bodies, whether thru cigarettes, chemical additives in food, or other carcinogens
                .لا نريد زعيما يخاف البيت الإبيض
                نريد زعيما يخاف الواحد الأحد
                دولة الإسلامية باقية





                Comment


                • #9
                  Re: HIV 'could destroy cancer cells'

                  Abu Mubarack is right, the tap water we drink, the medication in food, added hormones and saturated fat in our food,
                  the air we breathe. It all goes into your system and cancer only needs one defective cell to activate and due to this one
                  cell it starts to multiply abnormally.

                  I see cancer as a punishment from Allah because it's nearly impossible to detect before it's too late.

                  It's slow a painful death.

                  Three of my patients have cancer in their eyes and I had to refer them to a ophthalmologist to confirm.

                  It's very common these days.
                  Everyone thinks their a scholar because they know how to copy and paste, you get your ummah face on and the second you log out, you know your reality. Anyone can attain knowledge, how many can implement it?

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                  • #10
                    Re: HIV 'could destroy cancer cells'

                    cancer cells arise spontaneously ... they're not fully understood but the mechanism behind cell division is thought to undergo some complications and so non functional cells that multiply out of control are produced, and these are cancer cells ... the body makes them regularly too but they are usually destroyed by the body as well ....

                    HIV is different and is communicable as you probably know ... it actually came from eating animals like chimpanzees who are infected with a similar kind of disease ... but eventually it turned into the Human immunodeficiency virus ..

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                    • #11
                      Re: HIV 'could destroy cancer cells'

                      Nor is HIV a man made disease, as supported by the world wide medical community.

                      Comment


                      • #12
                        Re: HIV 'could destroy cancer cells'

                        Originally posted by Mich View Post
                        Nor is HIV a man made disease, as supported by the world wide medical community.
                        you dont know where aids comes from, you dont know where hiv comes from

                        from what the medical community has informed the world, it came from some homosexual europeans poking monkeys in africa

                        gimme a break

                        the various diseases that the USA has created and various forms of bio-warfare, aids is MOST LIKELY a result of the same people who say there are too many people on earth trying to purge the planet
                        .لا نريد زعيما يخاف البيت الإبيض
                        نريد زعيما يخاف الواحد الأحد
                        دولة الإسلامية باقية





                        Comment


                        • #13
                          Re: HIV 'could destroy cancer cells'

                          Originally posted by AbuMubarak View Post
                          you dont know where aids comes from, you dont know where hiv comes from

                          from what the medical community has informed the world, it came from some homosexual europeans poking monkeys in africa

                          gimme a break

                          the various diseases that the USA has created and various forms of bio-warfare, aids is MOST LIKELY a result of the same people who say there are too many people on earth trying to purge the planet
                          You are showing your racist attitude towards white people again. Where did you get your medical license from to make such judgments? Are you an expert in the spread of diseases to make such statements? What medical college did you attended? What organization of diseases and health do you belong to?

                          I am going to believe the medical doctors and the world wide medical community who spent years in study and research over your racist opinions and that of some conspiracy site that you will post or link.

                          WHILE YOU MAKE RACIST LIES ABOVE, in REALITY The WORLD medical community of the world has stated that HIV comes from hunters who kill, skin, and cut up various chimpanzees and apes because they are considered a delicacy (called bushmeat and see "hunter theory"). In studying the spread of the history of the disease, medical doctors of various countries in the world wide medical community have traced the earliest cases of HIV into Africa. If yo do some research, you can actually get the list of African countries where it first appeared.

                          A recent serological survey showed that human infections by SIV are not rare in Central Africa: the percentage of people showing seroreactivity to antigens- evidence of current or past SIV infection - was 2.3% among the general population of Cameroon, 7.8% in villages where bushmeat is practiced, and 17.1% in the most exposed people of these villages.
                          http://www.ncbi.nlm.nih.gov/pubmed/16485481
                          Last edited by Mich; 13-10-11, 11:47 PM.

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                          • #14
                            Re: HIV 'could destroy cancer cells'

                            People have been dying of Cancer since times immemorial irrespective of the fact that they have had lived under most hygenic and natural conditions. Cancer can be caused by a number of natural reasons. There are bacteria and viruses that can trigger causes and so are some spontaneous genetic mutations that can trigger cancer. Cancer may be caused by external reasons like radiation, smoking or carcinogenic substance but these are not the only ways.
                            Not knowing what one doesn't know will lead to difficulty

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                            • #15
                              Re: HIV 'could destroy cancer cells'

                              Please get real Abu. As Vishnu said, horrible diseases have plagued mankind since as long as we've been around.
                              Bubonic Plague wiped out 1/3 of Europeans during 14th century. Smallpox virus killed ~400,000,000 people in 20th century alone. HIV/AIDS death toll will most likely never even approach that number. And cancer has always been with us, since it results from our own cell DNA getting messed up, and there are many ways that can happen.

                              I don't think our bioengineering is/was advanced enough to create diseases from scratch, but people did breed especially lethal strains of bacteria for warfare purposes. And no, not just white people did it. Research unit 731 and see some stuff Japanese did. They had enough deadly anthrax to wipe the whole human population several times over.
                              Last edited by DonSmith; 14-10-11, 12:31 AM.

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