New England Journal of Medicine
Volume 352:558-569
February 10, 2005
Number 6




ABSTRACT


Background Antibodies against HLA antigens cause refractory allograft rejection with vasculopathy in some, but not all, patients.

Methods We studied 33 kidney-transplant recipients who had refractory vascular rejection. Thirteen had donor-specific anti-HLA antibodies, whereas 20 did not. Malignant hypertension was present in 16 of the patients without anti-HLA antibodies, 4 of whom had seizures. The remaining 17 patients had no malignant hypertension. We hypothesized that activating antibodies targeting the angiotensin II type 1 (AT1) receptor might be involved.

Results http://content.nejm.org/math/kgr.gifConclusions Source Information[email protected].

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  • Ingelfinger, J. R. (2005). Agonistic Autoantibodies and Rejection of Renal Allografts. N Engl J Med 352: 617-619[Full Text]