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German Scientists may have found a way to avoid rejection of transplants

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  • German Scientists may have found a way to avoid rejection of transplants

    New England Journal of Medicine
    Volume 352:558-569
    February 10, 2005
    Number 6




    ABSTRACT


    Background Antibodies against HLA antigens cause refractory allograft rejection with vasculopathy in some, but not all, patients.

    Methods We studied 33 kidney-transplant recipients who had refractory vascular rejection. Thirteen had donor-specific anti-HLA antibodies, whereas 20 did not. Malignant hypertension was present in 16 of the patients without anti-HLA antibodies, 4 of whom had seizures. The remaining 17 patients had no malignant hypertension. We hypothesized that activating antibodies targeting the angiotensin II type 1 (AT1) receptor might be involved.

    Results http://content.nejm.org/math/kgr.gifConclusions Source Information[email protected].

    Full Text of this Article

    This article has been cited by other articles:


    • Ingelfinger, J. R. (2005). Agonistic Autoantibodies and Rejection of Renal Allografts. N Engl J Med 352: 617-619[Full Text]



    Last edited by abdulhakeem; 11-02-05, 01:11 PM.
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