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Tea can help in fight against Alzheimer's, researchers conclude

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  • Tea can help in fight against Alzheimer's, researchers conclude

    By Terry Kirby, Chief Reporter
    26 October 2004


    It could be one of the most popular medicines to be prescribed. Research shows that the 196 million cups of tea which Britons consume every day could form a potent weapon in fighting Alzheimer's disease.

    Tea is already thought to protect the body against heart disease and cancers but research published yesterday shows black and green tea inhibit the activity of enzymes associated with the development of Alzheimer's, a form of dementia that affects about 10 million people around the world.

    The findings come in the wake of much research that suggest flavanoids contained in tea, particularly green tea, protect against strokes, heart attacks and many different types of cancers, as well as more prosaic conditions such as tooth decay and dehydration. One study shows that drinking three cups a day is the equivalent of eating six apples.

    Green and black tea derive from the same plant, Camellia sinensis, which is grown throughout the tropics but also in places such as Turkey. Black tea consists of fermented leaves, comes mainly from India and forms the basis of traditional types drunk in Britain such as Assam or Ceylon. Green tea is less processed and is popular in China and Japan, where it has been linked to longevity and low rates of heart disease and cancer.

    Scientists at Newcastle University's Medicinal Plant Research Centre found both teas inhibited the activity of the enzyme acetylcholinesterase (AChE), which breaks down the chemical messenger, or neurotransmitter, acetylcholine. Alzheimer's is characterised by reduced acetylcholine. Both teas also hinder the activity of the enzyme butyrylcholinesterase (BuChE), which has been found in protein deposits on the brains of patients with Alzheimer's.

    Green tea went one step further in obstructing the activity of beta-secretase, which helps produce protein deposits in the brain linked to Alzheimer's. The findings, published in Phytotherapy Research, could help in developing treatments for Alzheimer's. The researchers are seeking funds to further investigate green tea in the hope of creating a medicinal tea.

    Dr Ed Okello, the lead researcher and a green tea drinker himself, said: "Our findings are particularly exciting as tea is already a popular drink, it is inexpensive, and there do not seem to be any adverse side-effects.''

    WHAT'S IN YOUR CUP?

    GOOD:

    * Flavonoids: A type of anti-oxidant said to protect against certain types of heart disease and cancers.

    * Fluoride: Tea provides a higher proportion of our daily intake of fluoride, which prevents tooth decay, than toothpaste.

    BAD:

    * Tannins: Without milk, the tannin in tea binds to your insides, tanning them like leather; with milk, they bind to the milk's proteins.

    * Caffeine: Less than coffee, but more than Coke. Caffeine is said to aggravate heart conditions.

    http://news.independent.co.uk/uk/hea...p?story=576067
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  • #2
    Tea helps memory

    Ian Sample, science correspondent
    Tuesday October 26, 2004
    The Guardian

    Scientists have come up with the ideal riposte for those accused of taking too many tea breaks: tea keeps your brain healthy, they say. Tests on green and black tea suggest that regular tea drinking could help prevent age-related memory loss and keep dementias such as Alzheimer's disease at bay.

    Ed Okello and colleagues at the Medicinal Plant Research Centre at Newcastle University discovered that tea blocks brain enzymes that destroy acetylcholine, a neurotransmitter that carries messages between brain cells.

    Though scientists do not fully understand the causes of Alzheimer's disease, those affected have extremely low levels of acetylcholine in their brains. Drugs to treat the condition work by boosting the neurotransmitter back to normal levels. Normal age-related memory loss is also linked to a loss of acetylcholine.

    By halting the destruction of acetylcholine - a natural and necessary process in healthy brains - chemicals in tea could prevent levels of the neurotransmitter dropping too low.

    Black tea is derived from the same plant as green tea, but is fermented. Both types blocked two brain enzymes, while green tea also blocked the effects of a third. "The beneficial effects of green tea lasted for a week, but with black tea, the effect wore off after a day," said Dr Okello, whose study appears in the journal Phytotherapy Research.

    "If this works in the body like it does in the lab, anything like five to 10 cups of tea a day would help the levels of acetylcholine if you have too little," said Dr Okello.

    http://www.guardian.co.uk/uk_news/st...335893,00.html
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    • #3
      Cup of tea may help boost memory

      Last Updated: Monday, 25 October, 2004, 23:18 GMT 00:18 UK

      Drinking regular cups of tea could help improve your memory, research suggests.

      A team from Newcastle University found green and black tea inhibited the activity of key enzymes in the brain associated with memory.

      The researchers hope their findings, published in Phytotherapy Research, may lead to the development of a new treatment for Alzheimer's Disease.

      They say tea appears to have the same effect as drugs specifically designed to combat the condition.

      Alzheimer's disease is associated with a reduced level of a chemical called acetylcholine in the brain.

      In lab tests, the Newcastle team found that both green and black tea inhibited the activity of the enzyme acetylcholinesterase (AChE), which breaks down this key chemical.

      They also found both teas inhibited the activity of a second enzyme butyrylcholinesterase (BuChE), which has been discovered in protein deposits found in the brain of patients with Alzheimer's.

      Green tea went one step further in that it obstructed the activity of beta-secretase, which plays a role in the production of protein deposits in the brain which are associated with Alzheimer's disease.

      The scientists also found that it continued to have its inhibitive effect for a week, whereas black tea's enzyme-inhibiting properties lasted for only one day.

      Drugs work same way

      There is no cure for Alzheimer's but it is possible to slow the development of the disease.

      Drugs currently on the market hinder the activity of AChE, and others are being developed which scientists hope will inhibit the activity of BuChE and beta-secretase.

      However, many of the drugs currently available, such as donepezil, have unpleasant side effects and the medical profession is keen to find alternatives.

      The Newcastle University researchers are now seeking funding to carry out further tests on green tea, which they hope will include clinical trials.

      Their aim is to work towards the development of a medicinal tea which is specifically aimed at Alzheimer's sufferers.

      The next step is to find out exactly which components of green tea inhibit the activity of the enzymes AChE, BuChE and beta-secretase.

      Lead researcher Dr Ed Okello said: "Although there is no cure for Alzheimer's, tea could potentially be another weapon in the armoury which is used to treat this disease and slow down its development.

      "It would be wonderful if our work could help improve the quality of life for millions of sufferers and their carers.

      "Our findings are particularly exciting as tea is already a very popular drink, it is inexpensive, and there do not seem to be any adverse side effects when it is consumed.

      "Still, we expect it will be several years until we are able to produce anything marketable."

      Professor Clive Ballard, director of research, Alzheimer's Society, said: "This interesting research builds on previous evidence that suggests that green tea may be beneficial due to anti-oxidant properties.

      "Certainly the effect on the cholinesterase enzyme (the target of current anti-dementia drugs such as Aricept) and beta-secretase (an enzyme which is important in the build up of plaques) is very exciting and requires further investigation."

      Black tea - traditional English breakfast tea - is derived from the same plant as green tea, Camellia sinensis, but has a different taste and appearance because it is fermented.

      http://news.bbc.co.uk/1/hi/health/3951003.stm
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      • #4
        Tea drinking may protect against Alzheimers-study

        25 Oct 2004 23:01:03 GMT

        LONDON, Oct 25 (Reuters) - Drinking tea may help protect against Alzheimer's disease, though it is by no means a cure for the brain-crippling illness, British scientists said on Tuesday.

        Scientists at Newcastle University in England said their research shows that a regular "cuppa" could slow development of the affliction that fogs the memory of otherwise healthy people.

        "Although there is no cure for Alzheimer's, tea could potentially be another weapon in the armoury which is used to treat this disease and slow down its development," lead researcher Ed Okello said.

        They found that both green and black tea inhibited the activity of enzymes associated with the development of Alzheimer's disease, but that coffee had no significant effect.

        About one million people die from the illness annually and there is no known medical explanation for why it affects humans.

        Results of laboratory tests by the university's research team found that green and black tea inhibited the activity of the enzyme acetylcholinesterase (AChE), which breaks down the chemical messenger or neurotransmitter, acetylcholine -- Alzheimer's is characterised by a drop in acetylcholine.

        The scientists said green and black tea also hindered the activity of the enzyme butyrycholinesterase (BuChE), which has been discovered in protein deposits found on the brain of Alzheimer's patients.

        GREEN TEA FARES BETTER

        However, green tea scored better in several tests and had a longer-lasting affect, the research, showed which is published Tuesday in the academic journal, Phytotherapy Research.

        "Our findings are particularly exciting as tea is already a very popular drink, it is inexpensive, and there do not seem to be any adverse side effects when it is consumed. Still, we expect it will be several years until we are able to produce anything marketable," Okello said.

        The researchers said the next step is to find out exactly which components of green tea inhibit the activity of the enzymes AChE, BuChE and beta-secretase.

        Newcastle University is seeking funding to carry out further tests on green tea, which they hope will include clinical trials.

        Their aim is to work towards the development of a medicinal tea which is specifically aimed at Alzheimer's sufferers.

        http://www.alertnet.org/thenews/newsdesk/L25690635.htm
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        • #5
          :salams

          Blimey, I should have a photographic memory and 0% chance of Alzheimers by now. 2 sugars please.

          :wswrwb:
          Muslim while flying

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          • #6
            Re: Tea can help in fight against Alzheimer's, researchers conclude

            Sip Some Green Tea, Repair Brain Cells

            by Hana Levi Julian
            10/18/07

            (IsraelNN.com) Green tea has long been thought to have a healing effect on the human body. Now a study by an Israeli scientist has found proof in the laboratory of the Technion Institute of Science in Haifa.

            A research team led by Dr. Silvia Mandel of the Technion’s Eve Topf Center for Neurodegenerative Diseases found that green tea extract fed to mice with Parkinson’s and Alzheimer’s disease protected the brain cells from dying. It also stopped the process of degeneration in cells that were already affected.

            The Uruguay native, who immigrated to Israel in 1979, has studied the effects of green tea on health and healing for ten years, since she first began working at the research center.

            Mandel attended Ben Gurion University of the Negev, where she earned a degree in Biochemistry. She went on to receive a Masters Degree and then a PhD in Pharmacology at the Technion before joining the research center.

            It was during her first year at the center that Mandel found a study that indicated the EGCE in green tea extract could be used to prevent damage to red blood cells. That was the spark that set her on the journey to explore its effects on neurodegenerative disease.

            “I looked up some more articles and decided that maybe I could study this compound – in any event, it is natural so it can’t do any harm and it would be nice to tell people that they can drink something pleasant like tea and get beneficial effects from it,” she explained.

            The research findings in Mandel’s study showed that the main anti-oxidant polyphenol found in green tea extract, called EGCG, reduced compounds at the molecular level that lead to lesions in the brain. The amount of EGCG injected into the mice was equal to that found in approximately two to four cups of green tea per day.

            Her study, presented in September at the Fourth International Scientific Symposium on Tea and Human Health in Washington D.C., was one of the first to show the actual mechanism of EGCG when it enters the neurons in the brain.

            “It was received really well,” Mandel said in an interview with Israel21c. “It was novel in the sense that most studies presented dealt with how the consumption of tea impacts several parameters in patients affected with different maladies like cancer, diabetes and cardiovascular diseases.”

            Mandel also said a “neurorescue” study by one of her Ph.D. students, Lydia Reznichenko, showed EGCG not only prevented further deterioration of brain cells in mice affected with Parkinson’s disease, but also helped regenerate the neurons that were already damaged.

            “We’re the first to show that green tea is effective in doing this,” said Mandel. “In the past, it was thought that once brain cells were damaged, there was no way to repair them. The major question is whether these promising results are reproducible in humans.”

            http://www.israelnationalnews.com/News/News.aspx/123968
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            • #7
              Re: Tea can help in fight against Alzheimer's, researchers conclude

              One study shows that drinking three cups a day is the equivalent of eating six apples. ajeeb huh masha Allah all good news i practically live on tea
              "O you who believe! Stand out firmly for justice, as witnesses to Allah, even as against yourselves, or your parents, or your kin, and whether it be (against) rich or poor: for Allah can best protect both. Follow not the lusts (of your hearts), lest you swerve, and if you distort (justice) or decline to do justice, verily Allah is well-acquainted with all that you do." [An-Nisa 4:135]

              The Prophet :saw: said:

              "Whosoever leaves off obedience and separates from the Jamaa'ah and dies, he dies a death of jaahiliyyah. Whoever fights under the banner of the blind, becoming angry for 'asabiyyah (nationalism/tribalism/partisanship) or calling to 'asabiyyah, or assisting 'asabiyyah, then dies, he dies a death of jaahiliyyah."

              muslim

              Narrated 'Abdullah:

              The Prophet, said, "Abusing a Muslim is Fusuq (evil doing) and killing him is Kufr (disbelief)." sahih bukhari


              "Creeping upon you is the diseases of those people before you: envy and hatred. And hatred is the thing that shaves. I do not say it shaves the hair but it shaves the religion!

              By the One in whose Hand is my soul, you will not enter paradise until you believe, and you will not believe until you love one another. Certainly, let me inform you of that which may establish such things: spread the greetings and peace among yourselves."

              [Recorded by Imam Ahmad and Al-Tirmidhi]

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